GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs2076028 | 1 | rs5757234 | chr22:39072686 | TOMM22 | chr22:39077954-39080763:+ | -0.17 | -3.71 | 0.000236 | Resting heart rate |
| THCA | cis | rs2076028 | 1 | rs5757253 | chr22:39104320 | JOSD1 | chr22:39081549-39096459:- | -0.13 | -3.34 | 0.000893 | Resting heart rate |
| THCA | cis | rs2076028 | 1 | rs5757253 | chr22:39104320 | LOC646851 | chr22:38974125-39052634:- | 0.13 | 3.53 | 0.00046 | Resting heart rate |
| THCA | cis | rs2076028 | 1 | rs5757253 | chr22:39104320 | TOMM22 | chr22:39077954-39080763:+ | -0.16 | -3.57 | 0.000391 | Resting heart rate |
| THCA | cis | rs7742824 | 1 | rs57576544 | chr6:44072726 | TMEM63B | chr6:44095376-44123255:+ | 0.16 | 3.49 | 0.000524 | Major depressive disorder |
| THCA | cis | rs4889609 | 1 | rs57576577 | chr16:31036367 | C16orf93 | chr16:30768753-30773542:- | -0.15 | -4.34 | 1.77E-5 | Response to metformin (IC50) |
| THCA | cis | rs4889609 | 1 | rs57576577 | chr16:31036367 | HSD3B7 | chr16:30996519-31000473:+ | 0.48 | 12.46 | 4.53E-31 | Response to metformin (IC50) |
| THCA | cis | rs4889609 | 1 | rs57576577 | chr16:31036367 | MYST1 | chr16:31128985-31142713:+ | 0.16 | 5.39 | 1.1E-7 | Response to metformin (IC50) |
| THCA | cis | rs4889609 | 1 | rs57576577 | chr16:31036367 | PRSS53 | chr16:31094747-31106276:- | -0.15 | -4.15 | 3.92E-5 | Response to metformin (IC50) |
| THCA | cis | rs5758659 | 1 | rs5758659 | chr22:42622003 | C22orf32 | chr22:42475699-42480287:+ | 0.2 | 5.08 | 5.37E-7 | Cognitive function |
| THCA | cis | rs5758659 | 1 | rs5758659 | chr22:42622003 | CCDC134 | chr22:42196678-42222303:+ | 0.21 | 3.92 | 0.000103 | Cognitive function |
| THCA | cis | rs5758659 | 1 | rs5758659 | chr22:42622003 | CYP2D6 | chr22:42522502-42526883:- | -0.41 | -10.64 | 7.28E-24 | Cognitive function |
| THCA | cis | rs5758659 | 1 | rs5758659 | chr22:42622003 | NAGA | chr22:42454339-42466846:- | 0.35 | 7.49 | 3.29E-13 | Cognitive function |
| THCA | cis | rs5758659 | 1 | rs5758659 | chr22:42622003 | WBP2NL | chr22:42120334-42454460:+ | 0.25 | 4.58 | 6.0E-6 | Cognitive function |
| THCA | cis | rs5758659 | 1 | rs5758660 | chr22:42623718 | C22orf32 | chr22:42475699-42480287:+ | 0.2 | 5.31 | 1.73E-7 | Cognitive function |